{"title":"Klotho: The Longevity Peptide","description":"","products":[{"product_id":"reconstitution-xo-solution","title":"Reconstitution XO Solution","description":"\u003ch3\u003eOur advanced formula leverages the regenerative power of exosomes to enhance peptide stability and efficacy.\u003c\/h3\u003e\n\u003cp\u003eThis cutting-edge solution not only ensures the optimal delivery and potency of peptides but also provides additional support, promoting faster recovery and improved overall wellness.\u003c\/p\u003e\n\u003ch1 dir=\"ltr\"\u003e\u003cspan\u003eEnhancing Delivery of Peptides with Exosomes\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReconstituting with exosomes leverages their biological capabilities to enhance the efficacy of peptides by \u003c\/span\u003e\u003cspan\u003eimproving the peptides solubility and their delivery to cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen peptides have low solubility in water, they may not dissolve properly, leading to uneven distribution and dispersion, reducing their effectiveness. Further, poorly water soluble peptides can also degrade faster, thus limiting their potential.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eBy combining peptides with exosomes, their ability to mix with water improves significantly.\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis \u003c\/span\u003e\u003cspan\u003eensures that \u003c\/span\u003e\u003cspan\u003e\u003cspan style=\"background-color: rgb(255, 212, 0);\"\u003e\u003cstrong\u003eexosomes-loaded peptides are more evenly distributed in the body\u003c\/strong\u003e\u003c\/span\u003e, increasing their molecular stability, and their effectiveness\u003c\/span\u003e\u003cspan\u003e when reaching the cells. In addition, loading peptides in exosomes can maximize their delivery and entrance into cells, thus improving their benefits.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eExosomes, which are small extracellular vesicles, f\u003cspan style=\"background-color: rgb(255, 212, 0);\"\u003e\u003cstrong\u003eacilitate the targeted delivery and entrance of bioactive molecules into specific cells, thereby facilitating the effectiveness of peptides in cells.\u003c\/strong\u003e\u003c\/span\u003e This method capitalizes on the natural cellular communication pathways intrinsic to exosomes, promoting tissue regeneration, controlling inflammation, and improving overall cellular function.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eMaximize Benefits with Exosome-Reconstituted Peptides\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" role=\"presentation\"\u003e\n\u003cstrong\u003eEnhanced Cellular Delivery:\u003c\/strong\u003e\u003cspan\u003e Exosomes increase the likelihood of peptides reaching their target cells, improving the efficiency.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" role=\"presentation\"\u003e\n\u003cspan\u003e\u003cstrong\u003eImproved Solubility and Distribution in body:\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eHuman tissues are mainly composed of water,  thus solubility of partial hydrophobic peptides is enhanced, allowing for easier movement within the body and more uniform distribution in our solution.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" role=\"presentation\"\u003e\n\u003cspan\u003e\u003cstrong\u003eAugmented Peptide Entry:\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eExosome association helps the cellular entry of peptides, ensuring they reach intracellular targets more effectively.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" role=\"presentation\"\u003e\n\u003cstrong\u003eIncreased molecular Stability and Half-Life:\u003c\/strong\u003e\u003cspan\u003e Hydrophobic peptides exhibit higher stability and extended half-life when inserted into exosomes. Exosomes also shelter the peptides, protecting them from rapid degradation by extracellular enzymes, therefore enhancing their duration in the blood and other body tissues.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" role=\"presentation\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cb id=\"docs-internal-guid-1a394f16-7fff-ab92-31d5-9f24d5fac62f\"\u003e\u003cspan\u003eRegenerative Benefits: \u003c\/span\u003e\u003c\/b\u003eThe benefits of\u003ca href=\"https:\/\/genogenix.com\/hubfs\/Compound%20Overviews\/GenoGenix_Exosomes%20Compound%20Overview.pdf\"\u003e exosomes are well-documented\u003c\/a\u003e, supporting tissue repair and regeneration by delivering peptides to damaged or inflamed tissues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ca rel=\"noopener\" title=\"Download Scientific Research\" href=\"https:\/\/genogenix.com\/hubfs\/Company%20Documents\/GenoGenix%20Enhancing%20Delivery%20of%20Peptides%20through%20Exosome%20Reconstitution.pdf\" target=\"_blank\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0833\/2276\/5607\/files\/GenoGenix_Scientific_Research_supplements_nutraceuticals.svg?v=1725632302\" alt=\"\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eEstimated Exosomes Per Vial\u003c\/h3\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background-color: #44c8f5; color: white; height: 19.5938px;\"\u003e\n\u003cth style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003eVial Size\u003c\/th\u003e\n\u003cth style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003eStrength\u003c\/th\u003e\n\u003cth style=\"width: 40%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003eEst Exosomes\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e5mL\u003c\/td\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e10%\u003c\/td\u003e\n\u003ctd style=\"width: 40%; text-align: right; border: 1px solid #cccccc; padding: 8px;\"\u003e11,000,000,000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e10mL\u003c\/td\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e10%\u003c\/td\u003e\n\u003ctd style=\"width: 40%; text-align: right; border: 1px solid #cccccc; padding: 8px;\"\u003e22,000,000,000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e5mL\u003c\/td\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e20%\u003c\/td\u003e\n\u003ctd style=\"width: 40%; text-align: right; border: 1px solid #cccccc; padding: 8px;\"\u003e22,000,000,000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e10mL\u003c\/td\u003e\n\u003ctd style=\"width: 30%; text-align: center; border: 1px solid #cccccc; padding: 8px;\"\u003e20%\u003c\/td\u003e\n\u003ctd style=\"width: 40%; text-align: right; border: 1px solid #cccccc; padding: 8px;\"\u003e44,000,000,000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBUD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e6 months refrigerated\u003c\/li\u003e\n\u003cli\u003e2 years frozen\u003c\/li\u003e\n\u003cli\u003e5 years at -80° C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!----\u003e","brand":"GenoGenix","offers":[{"title":"10% Exosomes \/ 10 mL vial","offer_id":48724965490983,"sku":"INJ-RECEX10-10","price":697.0,"currency_code":"USD","in_stock":false},{"title":"10% Exosomes \/ 5 mL vial","offer_id":48724965523751,"sku":"INJ-RECEX10-05","price":413.0,"currency_code":"USD","in_stock":false},{"title":"20% Exosomes \/ 10 mL vial","offer_id":48724965589287,"sku":"INJ-RECEX20-10","price":1357.0,"currency_code":"USD","in_stock":false},{"title":"20% Exosomes \/ 5 mL vial","offer_id":48724965622055,"sku":"INJ-RECEX20-05","price":784.0,"currency_code":"USD","in_stock":false}]},{"product_id":"klotho-fg","title":"Klotho FG","description":"\u003c!-- Klotho FG --\u003e\n\u003cstyle\u003e\n  .grx-pd { \/* no font-size: inherits the theme's body text size so this block matches surrounding UI on both Shopify and Zoey *\/\n  max-width: 760px;\n  font-family: -apple-system, BlinkMacSystemFont, \"Segoe UI\", Roboto, Helvetica, Arial, sans-serif;\n  color: #1a1a1a;\n  line-height: 1.5;\n  }\n  .grx-pd__intro { font-size: 1em; margin: 0 0 1.75rem; } \/* em = relative to inherited body size *\/\n  .grx-pd__intro strong { color: #0f0f0f; }\n  \/* auto-fit grid: cards reflow from 1 col on mobile to 2 on wider screens without media queries *\/\n  .grx-pd__grid {\n  display: grid;\n  grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));\n  gap: 14px;\n  margin: 0 0 2rem;\n  }\n  .grx-pd__card {\n  background: #f7f8fa;\n  color: #3d3d3d;\n  border-radius: 0;\n  padding: 16px 18px;\n  font-size: 1em; \/* matches theme body text exactly *\/\n  transition: box-shadow .15s ease, transform .15s ease;\n  }\n  .grx-pd__card:hover { \/* subtle lift signals these are discrete data points, not a plain list *\/\n  box-shadow: 0 4px 14px rgba(0,0,0,.06);\n  }\n  .grx-pd__card-title { \/* larger + heavier than body so the mechanism reads first, body copy second *\/\n  display: block;\n  font-size: 1em;\n  font-weight: 700;\n  color: #0f0f0f;\n  margin: 0 0 .5rem;\n  line-height: 1.5;\n  }\n  \/* disclaimer intentionally low-contrast + small: legally present, visually de-emphasized *\/\n  .grx-pd__legal {\n  border-top: 1px solid #e6e8ec;\n  padding-top: 1.5rem;\n  font-size: 1em;\n  color: #6b7280;\n  line-height: 1.55;\n  }\n  .grx-pd__legal p { margin: 0 0 .6rem; font-size: 1em;}\n  .grx-pd__legal p:last-child { margin-bottom: 0; }\n \u003c\/style\u003e\n\n \u003cdiv class=\"grx-pd\"\u003e\n  \u003cp class=\"grx-pd__intro\"\u003e\n  \u003cstrong\u003eKlotho FG\u003c\/strong\u003e is a compounded preparation of the Klotho protein, a transmembrane enzyme known for its role in modulating cellular signaling pathways associated with aging and metabolic regulation. Klotho functions primarily as a co-receptor for fibroblast growth factors and influences ion transport and oxidative stress responses at the cellular level.\n  \u003c\/p\u003e\n\n  \u003cdiv class=\"grx-pd__grid\"\u003e\n  \u003cdiv class=\"grx-pd__card\"\u003e\n\u003cspan class=\"grx-pd__card-title\"\u003eFGF Signaling Regulation\u003c\/span\u003eKlotho has been studied for its role in regulating fibroblast growth factor (FGF) signaling pathways involved in cellular homeostasis.\u003c\/div\u003e\n  \u003cdiv class=\"grx-pd__card\"\u003e\n\u003cspan class=\"grx-pd__card-title\"\u003eAntioxidant Defense Modulation\u003c\/span\u003eKlotho is associated with supporting antioxidant defense mechanisms through modulation of reactive oxygen species.\u003c\/div\u003e\n  \u003cdiv class=\"grx-pd__card\"\u003e\n\u003cspan class=\"grx-pd__card-title\"\u003eIon Channel and Mineral Metabolism\u003c\/span\u003eKlotho has been evaluated in peer-reviewed literature for its potential role in maintaining ion channel activity and calcium\/phosphate metabolism.\u003c\/div\u003e\n  \u003cdiv class=\"grx-pd__card\"\u003e\n\u003cspan class=\"grx-pd__card-title\"\u003eLongevity and Metabolic Balance\u003c\/span\u003eKlotho may support cellular processes related to longevity and metabolic balance in preclinical models.\u003c\/div\u003e\n  \u003cdiv class=\"grx-pd__card\"\u003e\n\u003cspan class=\"grx-pd__card-title\"\u003eInflammatory Signaling Modulation\u003c\/span\u003eKlotho has been studied for its involvement in modulating inflammatory signaling cascades in animal studies.\u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv class=\"grx-pd__legal\"\u003e\n  \u003cp\u003eThis product is intended for use by licensed healthcare providers in clinical settings. It is not intended for consumer sale. Buyer\/doctor has determined and documented that the use of this product is appropriate for the patient based on the assessment of the patient's needs.\u003c\/p\u003e\n  \u003cp\u003eThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. For professional use only.\u003c\/p\u003e\n  \u003c\/div\u003e\n \u003c\/div\u003e","brand":"Nuceuticals Health","offers":[{"title":"10mg \/ vial \/ 8mL vial lyophilized","offer_id":48782502658343,"sku":"LYO-KLOFG10-08","price":345.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0833\/2276\/5607\/files\/nuc_klotho.png?v=1787583433"}],"url":"https:\/\/genogpo.com\/collections\/klotho-the-longevity-peptide.oembed","provider":"GenoGPO","version":"1.0","type":"link"}