This category contains neuroendocrine peptides and hormones that engage the hypothalamic-pituitary-gonadal axis and central melanocortin pathways to modulate reproductive function and arousal.

The products in this category target the central nervous system and gonadal tissues to influence sexual and reproductive physiology. 

Some interact centrally at MC3R and MC4R receptors in the hypothalamus, pathways associated with sexual desire and arousal signaling, operating through mechanisms distinct from peripheral vascular pathways. Others engage the HPG axis as upstream regulators, interacting with pathways involved in pulsatile GnRH release. Additional compounds bind the LH receptor on gonadal cells, interacting with pathways involved in endogenous testosterone and estrogen synthesis.